Osunprotafib
Product Specifications
CAS Number
2489404-97-7
Target
STAT|||JAK|||Phosphatase
Related Pathways
Angiogenesis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Metabolism
Purity
>99.99%
Bioactivity
Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]
Smiles
CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1
Molecular Formula
C17H24FN3O4S
Molecular Weight
385.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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