What is the catalog number for EGFR-IN-57?

The catalog number for EGFR-IN-57 is T61696.

What sizes are available for EGFR-IN-57?

EGFR-IN-57 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does EGFR-IN-57 come in?

EGFR-IN-57 is available in 3 different pack sizes.

Is EGFR-IN-57 in stock?

EGFR-IN-57 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures EGFR-IN-57?

EGFR-IN-57 is manufactured by Molfinity.

What is the estimated delivery time for EGFR-IN-57?

Estimated delivery time for EGFR-IN-57 is approximately 10 business day(s), depending on your location.

EGFR-IN-57

Product Specifications

CAS Number

2492382-37-1

Target

Others, Microtubule Associated, Apoptosis, VEGFR, Casein Kinase, EGFR, Topoisomerase

Related Pathways

Stem Cells, Angiogenesis, Apoptosis, Metabolism, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, JAK/STAT signaling, Others

Bioactivity

EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR tyrosine kinase (EGFR-TK) inhibitor with an IC50 of 0.054 μM. It also inhibits VEGFR-2, CK2α, topoisomerase IIβ, and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13, and 3.61 μM, respectively. The compound promotes cell cycle arrest at the G2/M and pre-G1 phases and induces apoptosis in cancer cells [1].