EGFR-IN-57

Product Specifications

CAS Number

2492382-37-1

Target

Others|||Microtubule Associated|||Apoptosis|||VEGFR|||Casein Kinase|||EGFR|||Topoisomerase

Related Pathways

Stem Cells|||Angiogenesis|||Apoptosis|||Metabolism|||DNA Damage/DNA Repair|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||JAK/STAT signaling|||Others

Bioactivity

EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR tyrosine kinase (EGFR-TK) inhibitor with an IC50 of 0.054 ?M. It also inhibits VEGFR-2, CK2?, topoisomerase II?, and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13, and 3.61 ?M, respectively. The compound promotes cell cycle arrest at the G2/M and pre-G1 phases and induces apoptosis in cancer cells [1].