EGFR-IN-57
Product Specifications
CAS Number
2492382-37-1
Target
Others|||Microtubule Associated|||Apoptosis|||VEGFR|||Casein Kinase|||EGFR|||Topoisomerase
Related Pathways
Stem Cells|||Angiogenesis|||Apoptosis|||Metabolism|||DNA Damage/DNA Repair|||Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||JAK/STAT signaling|||Others
Bioactivity
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR tyrosine kinase (EGFR-TK) inhibitor with an IC50 of 0.054 ?M. It also inhibits VEGFR-2, CK2?, topoisomerase II?, and tubulin polymerization with IC50 values of 0.087, 0.171, 0.13, and 3.61 ?M, respectively. The compound promotes cell cycle arrest at the G2/M and pre-G1 phases and induces apoptosis in cancer cells [1].
Smiles
C(C=1C2=C(C=C3C1C=CC=C3)C=CC=C2)=C4SC(NC=5C=C(C)ON5)=NC4=O
Molecular Formula
C22H15N3O2S
Molecular Weight
385.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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