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Tipiracil (hydrochloride)

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

Product Specifications

CAS Number

[183204-72-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tipiracil-hydrochloride.html

Purity

99.93

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O

Molecular Formula

C9H12Cl2N4O2

Molecular Weight

279.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13 (12) :e518-9.|[2]Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13 (10) :993-1001.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biomed Pharmacother. 2021 Jul:139:111672.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Mod Rheumatol. 2018 May;28 (3) :495-505.|Patent. US Patent 11110111.|Oncol Rep. 2023 Mar;49 (3) :52.

Available Sizes

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