Tipiracil (hydrochloride)
Product Specifications
UNSPSC Description
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Target Antigen
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tipiracil-hydrochloride.html
Purity
99.93
Solubility
DMF : < 1 mg/mL|DMSO : < 1 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O
Molecular Weight
279.12
References & Citations
[1]Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.|[2]Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.Biomed Pharmacother. 2021 May 6;139:111672.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Mod Rheumatol. 2018 May;28(3):495-505.|Patent. US Patent 11110111.|Oncol Rep. 2023 Mar;49(3):52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-A0063/Tipiracil-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-A0063/Tipiracil-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
183204-72-0
Available Sizes
Curated Selection
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