Tipiracil (hydrochloride)
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.
Product Specifications
CAS Number
183204-72-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Tipiracil-hydrochloride.html
Purity
99.93
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C1C(Cl)=C(CN2C(CCC2)=N)NC(N1)=O
Molecular Formula
C9H12Cl2N4O2
Molecular Weight
279.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13 (12) :e518-9.|[2]Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13 (10) :993-1001.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Biomed Pharmacother. 2021 Jul:139:111672.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Mod Rheumatol. 2018 May;28 (3) :495-505.|Patent. US Patent 11110111.|Oncol Rep. 2023 Mar;49 (3) :52.
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