PARP1-IN-10
Product Specifications
CAS Number
2494001-21-5
Target
Others|||PARP|||Apoptosis
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||Others|||DNA Damage/DNA Repair
Bioactivity
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor with an in vitro IC50 value of 50.62 nM, effectively inducing cell cycle arrest at the G2/M phase and apoptosis, while significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1].
Smiles
C(=C1C(=O)N(C)C(=O)N(C)C1=O)C2=CC=C(OCC(=O)N3CCCCC3)C=C2
Molecular Formula
C20H23N3O5
Molecular Weight
385.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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