EGFR-IN-52
Product Specifications
CAS Number
454436-75-0
Target
EGFR, Apoptosis, Others
Related Pathways
Others, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis
Bioactivity
EGFR-IN-52 (Compound 4) is a highly effective inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 0.358, 86.02, and 432.67 μM against EGFR, EGFR L858R-TK, and EGFR T790M-TK, respectively. Additionally, it demonstrates potent cytotoxic effects on cancer cell lines and triggers apoptosis [1].
Smiles
CN1N(C(=O)C(NC(=S)NC2=CC3=C(OCO3)C=C2)=C1C)C1=CC=CC=C1
Molecular Formula
C19H18N4O3S
Molecular Weight
382.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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