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EGFR-IN-52

Product Specifications

CAS Number

454436-75-0

Target

EGFR, Apoptosis, Others

Related Pathways

Others, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Apoptosis

Bioactivity

EGFR-IN-52 (Compound 4) is a highly effective inhibitor of the epidermal growth factor receptor (EGFR) with IC50 values of 0.358, 86.02, and 432.67 μM against EGFR, EGFR L858R-TK, and EGFR T790M-TK, respectively. Additionally, it demonstrates potent cytotoxic effects on cancer cell lines and triggers apoptosis [1].

Smiles

CN1N(C(=O)C(NC(=S)NC2=CC3=C(OCO3)C=C2)=C1C)C1=CC=CC=C1

Molecular Formula

C19H18N4O3S

Molecular Weight

382.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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