PKC-IN-4
Product Specifications
CAS Number
2636771-29-2
Target
Others, PKC
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Others
Bioactivity
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), with an IC 50 value of 0.52 μM. In vitro studies show that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α and impedes retinal vasculature permeability induced by both VEGF and TNF-α. [1]
Smiles
C(N)C1CCN(C2=C3C(SC4=C3CCCC4)=NC(=N2)C=5C=CN=CC5)CC1
Molecular Formula
C21H25N5S
Molecular Weight
379.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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Nucleoporin, 62kD, CT (NUP62, 62kD Nucleoporin, Nuclear Pore Glycoprotein p62, p62, DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, SNDI) (MaxLight 490)
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