XT2
Product Specifications
CAS Number
2582816-37-1
Target
Others|||NF-?B
Related Pathways
Others|||NF-?B
Bioactivity
XT2 is a highly potent, orally active, and selective inhibitor of NF-?B-inducing kinase (NIK), exhibiting an IC50 of 9.1 nM. It effectively suppresses the upregulation of ALT, a vital biomarker for acute liver injury, induced by CCl4. Additionally, XT2 significantly decreases immune cell infiltration into the damaged liver tissue. As a result, XT2 holds immense potential in liver inflammatory disease research [1].
Smiles
C[C@@](O)(C#Cc1ccc(F)c(c1)-c1c[nH]c2cnc(N)nc12)c1nccs1
Molecular Formula
C19H14FN5OS
Molecular Weight
379.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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