ATR-IN-15
Product Specifications
CAS Number
2756665-52-6
Target
Others|||ATM/ATR|||DNA-PK|||PI3K
Related Pathways
PI3K/Akt/mTOR signaling|||Others|||DNA Damage/DNA Repair
Bioactivity
ATR-IN-15 (compound 1) is a highly potent, orally active ATR kinase inhibitor with an IC50 of 8 nM. It also exhibits inhibitory activity against human colon tumor cells LoVo, DNA-PK, and PI3K, with IC50 values of 47, 663, and 5131 nM, respectively [1].
Smiles
CC=1N2C(=C(N1)C=3C=CNN3)N=C(C=C2N4[C@H](C)COCC4)C=5N(C)N=CC5
Molecular Formula
C19H22N8O
Molecular Weight
378.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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