TGFβ-IN-2
Product Specifications
CAS Number
2387678-02-4
Target
Others, TGF-beta/Smad
Related Pathways
Stem Cells, Others
Bioactivity
TGFβ-IN-2 (Compound 9d) effectively inhibits TGF-β-induced accumulation of total collagen in NRK-49F cells, with an IC50 value of 4.31 μM. It also suppresses the TGF-β-induced in vitro expression of COL1A1, α-SMA, and p-Smad3. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
Smiles
O(C=1C=2C(OC(=O)C1)=CC=CC2)C3=CC=C(NC(CN4CCCCC4)=O)C=C3
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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