GSK2646264
Product Specifications
CAS Number
1398695-47-0
Target
Others, VEGFR, GSK-3, JAK, LRRK2, Aurora Kinase, Syk, Src
Related Pathways
Autophagy, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Stem Cells, Others, PI3K/Akt/mTOR signaling, Angiogenesis, JAK/STAT signaling
Bioactivity
GSK2646264 (Compound 44) is a highly effective and specific inhibitor of spleen tyrosine kinase (SYK) with a pIC50 of 7.1. It also inhibits multiple kinases, including LCK (pIC50 5.4), LRRK2 (pIC50 5.4), GSK3β (pIC50 5.3), JAK2 (pIC50 5), VEGFR2 (pIC50 4.5), Aurora B (pIC50 <4.6), and Aurora A (pIC50 <4.3) . Notably, GSK2646264 demonstrates skin penetrability, reaching both the epidermis and dermis [1].
Smiles
COc1cccc(OCc2cc(C)ccn2)c1-c1ccc2CCNCCc2c1
Molecular Formula
C24H26N2O2
Molecular Weight
374.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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