PIM-1/HDAC-IN-1
Product Specifications
Target
Others, HDAC, Apoptosis, Pim
Related Pathways
JAK/STAT signaling, Chromatin/Epigenetic, DNA Damage/DNA Repair, Others, Apoptosis
Bioactivity
PIM-1/HDAC-IN-1 (compound 4d) is a potent PIM-1 inhibitor with an IC50 of 343.87 nM, and it exhibits strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. Additionally, it induces apoptosis and causes G2/M phase cell cycle arrest in MCF-7 cell lines, specifically inducing pre-G1 apoptosis [1].
Molecular Formula
C22H19N3O3
Molecular Weight
373.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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