Topoisomerase I inhibitor 5
Selected Variant
T61501-01
Size: 25 mg
Product Specifications
CAS Number
2513461-95-3
Target
Others, DNA/RNA Synthesis, Apoptosis, Topoisomerase
Related Pathways
Others, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
Topoisomerase I inhibitor 5 is an efficient topoisomerase I inhibitor with an IC50 value, effectively disrupting DNA and inhibiting topoisomerase I activity. It induces apoptosis in MCF-7 cells and arrests the cell cycle at the G1 phase, displaying potency in reversing P-gp-mediated resistance to Adriamycin [1].
Smiles
O(CCN1C(C)CCCC1)C=2C=3C4=C(C=5C(C(=O)C4=CC2)=CC=CC5)N=CC3
Molecular Formula
C24H24N2O2
Molecular Weight
372.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Price
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