TOPK-p38/JNK-IN-1
Product Specifications
CAS Number
2745108-35-2
Target
JNK|||Others
Related Pathways
MAPK|||Others
Bioactivity
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, exhibiting an IC50 of 2.14 ?M for NO production inhibition. It demonstrates anti-inflammatory properties by inhibiting downstream protein phosphorylation and preventing TOPK degradation [1].
Smiles
N(C(NC1=CC(C(F)(F)F)=CC=C1)=O)C2=C(OC)C=C(O)C(C(C)=O)=C2
Molecular Formula
C17H15F3N2O4
Molecular Weight
368.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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