Topoisomerase IIα-IN-4
Product Specifications
Target
Apoptosis, Others, Topoisomerase
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Others
Bioactivity
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, selectively inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It induces apoptosis and arrests the cell cycle in HepG2 cells, demonstrating strong antitumor effects against various human cancer cell lines, thereby highlighting its significance for cancer research [1].
Molecular Formula
C25H21NO2
Molecular Weight
367.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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