CXCR4 antagonist 6
Product Specifications
CAS Number
2304750-68-1
Target
Others, CXCR
Related Pathways
Immunology/Inflammation, Others, Autophagy, GPCR/G Protein
Purity
1
Bioactivity
CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM, effectively inhibiting the cytosolic calcium flux induced by CXCL12 with an IC50 of 0.25 nM. Additionally, it significantly mitigates cell migration mediated by the CXCL12/CXCR4 interaction and demonstrates remarkable efficacy in a mouse model of cancer metastasis [1].
Smiles
C(N1[C@@H](CCC1)C2=C(C)C=CC=N2)C=3C=C(N=C(C)N3)N4CCN(C)CC4
Molecular Formula
C21H30N6
Molecular Weight
366.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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