CXCR4 antagonist 5
Product Specifications
CAS Number
2304749-86-6
Target
Others, CXCR
Related Pathways
Others, Autophagy, Immunology/Inflammation, GPCR/G Protein
Bioactivity
CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and hinders CXCR4/CXCL12-mediated chemotaxis. Moreover, Compound 23 demonstrates favorable physicochemical properties and in vitro safety profiles, exhibiting only marginal to moderate inhibition of CYP isozymes and hERG [1].
Smiles
N(CC=1C=C(N=C(C)N1)N2CCN(C)CC2)(C)[C@@H]3C=4C(CCC3)=CC=CN4
Molecular Formula
C21H30N6
Molecular Weight
366.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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