Fasudil dihydrochloride
Product Specifications
CAS Number
203911-27-7
Target
ROCK, Rho, PKA, PKC
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Cell Cycle/Checkpoint, Stem Cells
Purity
0.9986
Bioactivity
Fasudil dihydrochloride, also known as HA-1077 and AT877, is a nonspecific inhibitor of RhoA/ROCK. Fasudil dihydrochloride exhibits inhibitory effects on protein kinases including ROCK1 (Ki = 0.33 μM), ROCK2 (IC50 = 0.158 μM), PKA (IC50 = 4.58 μM), PKC (IC50 = 12.30 μM), and PKG (IC50 = 1.650 μM), while also acting as a potent Ca2+ channel blocker and vasodilator, providing a multifunctional pharmacological tool for vascular, cardiovascular, and cellular signaling research.
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O.Cl.Cl
Molecular Formula
C14H19Cl2N3O2S
Molecular Weight
364.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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