What is the catalog number for P53 Activator 2?

The catalog number for P53 Activator 2 is T61369.

What sizes are available for P53 Activator 2?

P53 Activator 2 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does P53 Activator 2 come in?

P53 Activator 2 is available in 3 different pack sizes.

Is P53 Activator 2 in stock?

P53 Activator 2 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P53 Activator 2?

P53 Activator 2 is manufactured by Molfinity.

What is the estimated delivery time for P53 Activator 2?

Estimated delivery time for P53 Activator 2 is approximately 10 business day(s), depending on your location.

P53 Activator 2

Product Specifications

CAS Number

2338764-89-7

Target

MDM-2/p53, Apoptosis, Others, DNA/RNA Synthesis

Related Pathways

Apoptosis, Others, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

P53 Activator 2 (compound 10ah) intercalates into DNA, causing significant double-strand breaks and upregulating the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces apoptosis, reduces anti-apoptosis proteins Bcl-2, Bcl-xL, and cyclin B1 levels, and shows anti-proliferative activity against MGC-803 cells with an IC50 of 1.73 μM. Additionally, p53 Activator 2 exhibits potent anticancer effectiveness in MGC-803 xenograft tumor models [1].