AKN-028 acetate
Product Specifications
Target
Others, Caspase, Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Proteases/Proteasome, Others, Apoptosis, Angiogenesis
Bioactivity
AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response (mean IC50 = 1 μM) . AKN-028 acetate also induces apoptosis by activation of caspase 3 and can be used in acute myeloid leukemia (AML) research [1].
Molecular Formula
C19H18N6O2
Molecular Weight
362.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
P503444 100 µg
EBV/HHV4 GP42/Glyco 42 Protein (C-His, Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) )
Sign In for Pricing
View Details 
28284111 3x 1.0 µg
MECOM sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
Sign In for Pricing
View Details