SRI-41315
Product Specifications
CAS Number
1613509-49-1
Target
CFTR
Related Pathways
Membrane transporter/Ion channel
Purity
0.9987
Bioactivity
SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14
Smiles
O=C1C=2C=CC=CC2N(C=3N=C(N(C=4C=CC=CC4)C(=O)C13)C5CCC5)C
Molecular Formula
C22H19N3O2
Molecular Weight
357.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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