ARN1468
Product Specifications
CAS Number
1381459-14-8
Target
PAI-1, Others
Related Pathways
Metabolism, Others
Bioactivity
ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
Smiles
NC1=C(C=NN1C1=CC=C(OC(F)(F)F)C=C1)C(=O)C1CCNCC1
Molecular Formula
C16H17F3N4O2
Molecular Weight
354.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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