AChE/BChE/BACE-1-IN-1
Product Specifications
CAS Number
1321361-13-0
Target
Beta-Secretase|||Cholinesterase (ChE) |||ROS Kinase|||Others
Related Pathways
Others|||Neuroscience|||Tyrosine Kinase/Adaptors
Bioactivity
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and ?-site amyloid precursor protein cleaving enzyme 1 (BACE-1), with IC50 values of 0.058 ?M, 0.082 ?M, and 0.115 ?M against hAChE, hBChE, and hBACE-1, respectively. It exhibits significant binding affinity with PAS-AChE, excellent blood-brain barrier permeability, potential disassembly of amyloid-beta (A?) aggregates, neuroprotective properties against A?-induced stress, and remarkable antioxidant capabilities [1].
Smiles
C(N1CC(NCC2=CC=C(OC(F)(F)F)C=C2)CC1)C3=CC=CC=C3
Molecular Formula
C19H21F3N2O
Molecular Weight
350.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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