ALK5-IN-8
Product Specifications
CAS Number
2705900-81-6
Target
Others, TGF-beta/Smad
Related Pathways
Others, Stem Cells
Bioactivity
ALK5-IN-8 is a highly effective inhibitor of TGFβRI (ALK5) . It hinders the phosphorylation of ALK5 on downstream signaling proteins (Smad2 or Smad3) by obstructing the interaction between TGFβRI and ligands. Consequently, it disrupts or prevents TGF-β signaling. ALK5-IN-8 shows promise in the study of diverse diseases associated with ALK5-mediated pathways[1].
Smiles
C(OCC)(=O)C1=C2N(N=C1)C=CC(=C2)C=3C(=NNC3)C4=CC=C(F)C=C4
Molecular Formula
C19H15FN4O2
Molecular Weight
350.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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