Irdabisant hydrochloride
Product Specifications
CAS Number
1005398-61-7
Target
Histamine Receptor|||Others
Related Pathways
Immunology/Inflammation|||Neuroscience|||GPCR/G Protein|||Others
Bioactivity
Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier penetrating histamine H3 receptor (H3R) inverse agonist, demonstrating high affinity with K*i values of 7.2 nM and 2.0 nM for rat and human H3R, respectively. Exhibiting relatively low hERG current inhibitory activity with an IC*50 of 13.8 ?M, this compound has shown to enhance cognition and promote wakefulness in rat social recognition models, suggesting potential applications in schizophrenia or cognitive impairment research.
Smiles
Cl.C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1
Molecular Formula
C18H24ClN3O2
Molecular Weight
349.86
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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