NMD670
NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue[1][2].
Product Specifications
CAS Number
[2354321-33-6]
UNSPSC
12352005
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmd670.html
Purity
99.60
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@H](C)OC1=CC=C(Br)C=C1C2=NOC=C2)=O
Molecular Formula
C12H10BrNO4
Molecular Weight
312.12
References & Citations
[1]Skov M, et al. The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Sci Transl Med. 2024 Mar 20;16 (739) :eadk9109.|[2]Chin E, et al. Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial. Clin Pharmacol Ther. 2024 Dec 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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