NMD670

NMD670 is an orally active inhibitor of skeletal muscle specific chloride channel ClC-1 with an EC50 of 1.6 μM. NMD670 enhances neuromuscular transmission and improves muscle contraction and strength. NMD670 can be used in the study of muscle weakness and muscle fatigue[1][2].

Product Specifications

CAS Number

[2354321-33-6]

UNSPSC

12352005

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nmd670.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@H](C)OC1=CC=C(Br)C=C1C2=NOC=C2)=O

Molecular Formula

C12H10BrNO4

Molecular Weight

312.12

References & Citations

[1]Skov M, et al. The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis. Sci Transl Med. 2024 Mar 20;16 (739) :eadk9109.|[2]Chin E, et al. Safety, Pharmacokinetics, and Pharmacodynamics of a First-in-Class ClC-1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial. Clin Pharmacol Ther. 2024 Dec 9.