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NM23A Rabbit rabbit pAb

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008],

Product Specifications

Background

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

Synonyms

NME1

Gene ID

4830

UniProt

P15531

Cellular Locus

Cytoplasm. Nucleus. Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Host

Rabbit

Species Reactivity

Human,Rat,Mouse

Reactivity

Human; Rat; Mouse

Immunogen

Recombinant Protein of NM23A of NME1

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

IHC, IF

Validated Applications

IHC,IF

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

IHC 1:100-200

Molecular Weight

17kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20658-1.pdf

Observed Molecular Weight

17 kD

Subcellular Location

Cytoplasm . Nucleus . Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Other Product Names

NME1

Gene ID (Human)

4830

SwissProt (Human)

P15531

Available Sizes

Curated Selection

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