SCH-42354
Product Specifications
CAS Number
144505-58-8
Target
Neprilysin|||Others
Related Pathways
Others|||Metabolism
Bioactivity
SCH-42354 is a potent, orally active inhibitor of neutral endopeptidase (NEP), serving as the active form of the prodrug SCH-42495. By inhibiting NEP hydrolysis, SCH-42354 enhances the activity of atrial natriuretic peptide (ANP) and prevents the hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. Furthermore, SCH-42354 exhibits antihypertensive activity [1] [2].
Smiles
C([C@@H](C(N[C@@H](CCSC)C(O)=O)=O)CS)C1=C(C)C=CC=C1
Molecular Formula
C16H23NO3S2
Molecular Weight
341.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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