MurB-IN-1

MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of the bacterial cell wall. With a binding affinity of Kd 3.57 ?M, MurB-IN-1 effectively hinders MurB activity, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1].