JH295 hydrate
Product Specifications
Target
MAPK, Others
Related Pathways
MAPK, Others
Bioactivity
JH295 hydrate is a potent, irreversible, and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM) . JH295 hydrate is not active against the mitotic kinases Cdk1, Aurora B, or Plk1, and does not interfere with bipolar spindle assembly or the spindle assembly checkpoint [1].
Molecular Formula
C18H18N4O3
Molecular Weight
338.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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