Type II topoisomerase inhibitor 1
Product Specifications
CAS Number
2245691-60-3
Target
Topoisomerase, Antibacterial, Others, DNA/RNA Synthesis
Related Pathways
Microbiology/Virology, Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair
Bioactivity
Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with an IC50 value of 1.7 nM and forms hydrogen bonds with the Asp73 residue. It inhibits topoisomerase IV activity with an IC50 value of 0.98 μM and is applicable in the antibacterial area [1] [2].
Smiles
N(C)C1=C2C(C=C(C(NC3=CC=C(C(O)=O)C=C3)=O)C(=O)N2)=CC=C1
Molecular Formula
C18H15N3O4
Molecular Weight
337.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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