TP0427736 hydrochloride
Product Specifications
CAS Number
2459963-17-6
Target
ALK, TGF-beta/Smad
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells
Purity
0.9899
Bioactivity
TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.
Smiles
Cl.N1=CSC=2C=C(C=CC12)C=3NC=NC3C4=NC(=CS4)C
Molecular Formula
C14H11ClN4S2
Molecular Weight
334.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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