Izuforant
Product Specifications
CAS Number
1429374-83-3
Target
Others, Histamine Receptor
Related Pathways
GPCR/G Protein, Others, Neuroscience, Immunology/Inflammation
Bioactivity
Izuforant (JW1601) (Compound 24) exhibits potent anti-inflammatory and anti-pruritic activities, with a binding affinity for human serotonin 3 receptor (h5-HT3R) and an IC50 value of 9.1 μM. It is also an orally active antagonist of histamine H4 receptor (H4R), showing an IC50 value of 36 nM against human H4R [1] [2].
Smiles
N(C)C1CN(C=2C=3N(C=4C(N2)=NC=C(Br)C4)C=NN3)C1
Molecular Formula
C12H12BrN7
Molecular Weight
334.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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