Torin 2
Product Specifications
CAS Number
1223001-51-1
Target
DNA-PK, Apoptosis, mTOR, ATM/ATR, Autophagy
Related Pathways
DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Autophagy, Apoptosis
Purity
0.9947
Bioactivity
Torin 2 (IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 28 nM/35 nM/118 nM, respectively.
Smiles
Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
Molecular Formula
C24H15F3N4O
Molecular Weight
432.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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