Verosudil
Product Specifications
CAS Number
1414854-42-4
Target
ROCK
Related Pathways
Cytoskeletal Signaling, Cell Cycle/Checkpoint, Stem Cells
Purity
0.9972
Bioactivity
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 nM and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 mitigates steroid-induced intraocular pressure in mice by decreasing intraocular pressure through enhanced outflow of aqueous humor via the trabecular meshwork.
Smiles
CN(C)C(C(=O)Nc1ccc2c(cc[nH]c2=O)c1)c1ccsc1
Molecular Formula
C17H17N3O2S
Molecular Weight
327.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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