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THK-5117

Product Specifications

CAS Number

1374107-54-6

Target

Microtubule Associated, Others

Related Pathways

Others, Cytoskeletal Signaling

Bioactivity

THK-5117 is an arylquinoline derivative with the potential as a PET probe for tau imaging. THK-5117 shows high binding affinity to tau fibrils with a Ki value of 10.5 nM. THK-5117 also shows high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD) brain homogenates [1].

Smiles

O(CC(CF)O)C1=CC2=C(N=C(C=C2)C3=CC=C(NC)C=C3)C=C1

Molecular Formula

C19H19FN2O2

Molecular Weight

326.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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