NiCur
Product Specifications
CAS Number
2674753-39-8
Target
Apoptosis, PARP, Caspase, Epigenetic Reader Domain, Histone Acetyltransferase
Related Pathways
Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9922
Bioactivity
NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM. NiCur blocks CBP HAT activity, downregulates p53 activation and inhibits apoptosis, while promoting methylation of Lysine 27 on histone H3, inhibiting Caspase 3 activity and PARP cleavage.
Smiles
C(=C\1/C(=O)\C(=C\C2=CC(C#N)=CC=C2)\CCC1)\C3=CC(C#N)=CC=C3
Molecular Formula
C22H16N2O
Molecular Weight
324.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
QM5069 150 Reactions
ViPrimePLUS Respiratory Syncytial Virus Type A RT-qPCR Kit
Sign In for Pricing
View Details 
bs-22547R-BF405 100 µL
Hydrogen exchanger 3 Polyclonal Antibody, AbBy Fluor™ 405 Conjugated
Sign In for Pricing
View Details 
RC218642L4V 200 µL
BSPRY (NM_017688) Human Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details LV764198 1.0 µg DNA
IGHV3-37 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
Sign In for Pricing
View Details