NiCur
Product Specifications
CAS Number
2674753-39-8
Target
Apoptosis, PARP, Caspase, Epigenetic Reader Domain, Histone Acetyltransferase
Related Pathways
Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9922
Bioactivity
NiCur is an effective and selective inhibitor of CBP histone acetyltransferase (HAT), with an IC50 of 0.35 μM. NiCur blocks CBP HAT activity, downregulates p53 activation and inhibits apoptosis, while promoting methylation of Lysine 27 on histone H3, inhibiting Caspase 3 activity and PARP cleavage.
Smiles
C(=C\1/C(=O)\C(=C\C2=CC(C#N)=CC=C2)\CCC1)\C3=CC(C#N)=CC=C3
Molecular Formula
C22H16N2O
Molecular Weight
324.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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