PT4
Product Specifications
CAS Number
1280738-47-7
Target
Others|||Parasite|||Reactive Oxygen Species
Related Pathways
NF-?B|||Others|||Metabolism|||Immunology/Inflammation|||Microbiology/Virology
Bioactivity
PT4 is a treatment agent for Cutaneous leishmaniasis (CL) . PT4 decreases of mitochondrial membrane potential and increases reactive oxygen species production, therefore leads to parasite death. PT4 is effective against both species of Leishmania. The IC50 values of PT4 against L. amazonensis and L. braziliensis are 125.18 and 233.18 ?M , respectively. PT4 also shows potent anti-inflammatory activity in vivo [1].
Smiles
O=C1C=2C(C(=O)N1CCN3C=C(N=N3)C4=CC=CC=C4)=CC=CC2
Molecular Formula
C18H14N4O2
Molecular Weight
318.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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