TPBM
Product Specifications
CAS Number
6466-43-9
Target
Estrogen Receptor/ERR, Others
Related Pathways
Others, Endocrinology/Hormones
Bioactivity
TPBM is a potent inhibitor of estrogen receptor α (ERα) . The IC 50 value of TPBM for 17β-estradiol (E2) -ERα is 9 μM. TPBM is not toxic to cells and reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells with an IC 50 value of 5 μM. TPBM does not affect estrogen-independent cell growth [1].
Smiles
O=C1C2=C(N=C(CSCC3=CC=CC=C3)N2)N(C)C(=O)N1C
Molecular Formula
C15H16N4O2S
Molecular Weight
316.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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