Peldesine dihydrochloride
Product Specifications
CAS Number
2772702-10-8
Target
Others, Nucleoside Antimetabolite/Analog, HIV Protease
Related Pathways
Cell Cycle/Checkpoint, Proteases/Proteasome, Microbiology/Virology, DNA Damage/DNA Repair, Others
Bioactivity
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), with IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mouse red blood cell (RBC) PNP, respectively. Additionally, it inhibits T-cell proliferation with an IC50 of 800 nM, showing promise for research into cutaneous T-cell lymphoma, psoriasis, and HIV infection [1] [2] [3] [4].
Smiles
Cl.Cl.Nc1nc(=O)c2[nH]cc(Cc3cccnc3)c2[nH]1
Molecular Formula
C12H13Cl2N5O
Molecular Weight
314.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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