EM127
Product Specifications
CAS Number
1886879-71-5
Target
ERK, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, MAPK
Purity
0.9761
Bioactivity
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methyltransferase activity over a long period of time.EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors. EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors.
Smiles
ClCC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1
Molecular Formula
C14H18ClN3O3
Molecular Weight
311.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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