EM127
Product Specifications
CAS Number
1886879-71-5
Target
ERK, Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic, MAPK
Purity
0.9761
Bioactivity
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional regulation of SMYD3 target genes.EM127 slowly reduces methyltransferase activity over a long period of time.EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors. EM127 has potential anticancer activity and can be used to study SMYD3 positive tumors.
Smiles
ClCC(=O)N1CCC(CC1)NC(=O)c1cc(on1)C1CC1
Molecular Formula
C14H18ClN3O3
Molecular Weight
311.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2154655-01 96 Tests
Interleukin 5 (IL5) Magnetic Fluorescence Assay Kit
Sign In for Pricing
View Details MBS2154655-02 5x 96 Tests
Interleukin 5 (IL5) Magnetic Fluorescence Assay Kit
Sign In for Pricing
View Details MBS2154655-03 10x 96 Tests
Interleukin 5 (IL5) Magnetic Fluorescence Assay Kit
Sign In for Pricing
View Details 
VP 750AC-SLAS 1 EACH
BUBBLE PADDLE RESERVOIR, Tumble Powered, 96 Channel, White Acetal Reservoir, with 4 Bubble Paddles, Parylene Coated, 13 Bubbles/Paddle, Mixes 300mL, SLAS Footprint
Sign In for Pricing
View Details 