ZM-447439
Product Specifications
CAS Number
331771-20-1
Target
Src, Apoptosis, Aurora Kinase, MEK
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, MAPK, Angiogenesis, Cell Cycle/Checkpoint, Apoptosis
Purity
0.9959
Bioactivity
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect against CDK1/2/4, Plk1, Chk1, etc.
Smiles
COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1
Molecular Formula
C29H31N5O4
Molecular Weight
513.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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