Epothilone B
Product Specifications
CAS Number
152044-54-7
Target
Apoptosis, Microtubule Associated, Antifungal, Antibacterial, Antibiotic
Related Pathways
Cytoskeletal Signaling, Apoptosis, Microbiology/Virology
Purity
0.9984
Bioactivity
Epothilone B (EPO 906) is a compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, patupilone induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Patupilone may cause complete cell-cycle arrest.
Smiles
C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)C(\C)=C\c1csc(C)n1
Molecular Formula
C27H41NO6S
Molecular Weight
507.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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