(E/Z) -Rigosertib sodium
Product Specifications
CAS Number
1225497-78-8
Target
PLK
Related Pathways
Cell Cycle/Checkpoint
Purity
0.9982
Bioactivity
ON-01910 is a non-ATP-competitive PLK1 inhibitor (IC50 of 9 nM, in a cell-free assay) . It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Smiles
[Na+].COc1cc(OC)c(C=CS(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1
Molecular Formula
C21H24NNaO8S
Molecular Weight
473.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/B2209668-5013-494C-8E1A-FC62FAA8C7AA/T6070
Available Sizes
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